The first emulator I tried on the Ouya was PCE.emu. Its CD compatibility so far has been perfect. Every game in my TG16/PC Engine CD colllection works and losing the early 90s CD drive load times has been very welcome. The Sega equivalent, MD.emu, has been a bit more spotty. It is based on Genesis Plus which advertizes 100% compatibility so I don't know if the CD compatibility is different on other source ports. From poking around random Android emulation forums I've confirmed that my CD compatibility is consistent with what others have experienced.
This is limited to games I actually own. In my last article I noted that MD.emu is picky about how Sega CD games are ripped so I can't trust that ones from another source were done in a compatible way. I'm not remotely close to owning a complete Sega CD collection but I think this is a good enough sampling to represent what works & what doesn't. I also didn't play any of these games all the way through but went far enough to find any catastrophic issues.
Afterburner III
No issues.
AH3 Thunderstrike
No issues.
Bill Walsh College Football
No issues.
Bouncers
No issues.
Chuck Rock 2
No issues.
Compton's Interactive Encyclopedia
No issues.
Demolition Man
No issues.
Dune
No issues.
Dunegon Explorer
No issues.
ESPN National Hockey Night
No issues.
ESPN NBA Hangtime
No issues.
Eternal Champions
No issues.
Eye of the Beholder
No issues.
Flashback
No issues.
Ground Zero Texas
No issues.
Heimdall
No issues.
Hook
No issues.
Iron Helix
No issues.
Jaguar XJ220
No issues.
Jeopardy!
No issues
Joe Montana's NFL Football
No issues.
Lunar: The Silver Star
No issues.
Mansion of Hidden Souls
No issues.
Midnight Raiders
No issues.
NBA Jam
No issues.
Penn & Teller's Smoke and Mirrors
OK, I obviously didn't rip this one. This is the version that leaked to the internet a few years ago. Everything works fine in MD.emu.
Pitfall: The Mayan Adventure
No issues.
Racing Aces
Title screen was funky but it played fine.
RDF Global Conflict
No issues.
Rise of the Dragon
No issues.
Robo Aleste
No issues.
Samurai Shodown
No issues.
Shining Force CD
No issues, although I got bored before getting to any actual gameplay. Apologies to all the die-hard fans of this series.
Sonic CD
No issues.
Spider-Man vs Kingpin
No issues.
Star Wars: Rebel Assault
No issues.
Stellar Fire
No issues.
Surgical Strike
No issues.
The Animals
No issues.
Third World War
No issues.
Wirehead
No issues.
Wonder Dog
No issues.
Crime Patrol
Plays fine, loud static noises instead of some sound effects.
Ecco the Dolphin
Graphical glitches but playable.
Ecco the Tides of Time
Graphical glitches but playable.
FIFA International Soccer
Graphical glitches but playable.
Mad Dog McCree
Plays fine, loud static noises instead of some sound effects.
Marky Mark n' Da Funky Bunch Make My Video
Choppy video and audio but playable.
Prince of Persia
Plays fine, horrible static throughout game so you need to mute it.
Sega Classics 5-in-1
Revenge of Shinobi doesn't start.
Sherlock Holmes Consulting Detective
All the scenes stop playing after a few seconds but the game itself can be continued by pressing any button.
Soul Star
Graphical glitches but playable.
Star Wars Chess
The battles scenes have distorted graphics and freeze, if you cancel them before they start the game is otherwise fine.
Black Hole Assault
Opening cinema plays, game freezes before a fight starts.
Chuck Rock
Severe graphical glitches, unplayable.
Double Switch
Freezes on blank screen after Sega logo.
ESPN Sunday Night NFL
Severe graphical glitches, unplayable.
Kids on Site
Freezes on Sega logo.
Lunar: Eternal Blue
Freezes at Working Designs logo with the first few seconds of music looping.
Mighty Morphin Power Rangers
Freezes on blank screen after opening cinema.
Mortal Kombat
Game freezes after opening cinema, trying to skip it also freezes.
NFL Trivia
On the menu screen the first few seconds of music loops endlessly and input doesn't register.
NFL's Greatest: San Francisco vs. Dallas
Freezes after opening kickoff.
NHL '94
Freezes on blank screen after Sega logo.
Panic
Freezes on blank screen after Sega logo.
Panic
Freezes on blank screen after Sega logo
Power Monger
Freezes on Sega logo.
Silpheed
Freezes after opening cinema.
The Secret of Monkey Island
Either I completely forgot how to play this game or the controls don't work.
Vay
Opening cinema played fine, game froze during the first dialog.
Wheel of Fortune
Froze when it was time to spin the titular wheel.
The Adventures of Willy Beamish
Severe graphical glitches, unplayable.
WWF Rage in the Cage
Freezes when loading a match.
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